Hyperkeratosis? Nose butter? Who knew? There it was, part of a scary reaction to a once monthly prescription flea medicine (NEVER again-goin all natural). It took about 3 days after we got your nose butter. Meanwhile, I was using my own “nose butter” (more like nose lotion), made from coconut oil and a touch of olive oil. But, it didn’t help very long at a time. I was applying it every 2 hours plus once or twice at night when I had to get up anyway. She’s a sweetheart and a wise little thing, but my husky/corgi mix and I were both tired of that. My Blissful Every Dog nose butter arrived in less than a week. It just seemed like forever, lol. I found tho that her dry nose problem was as resistant as the soles of my feet were before I found what worked for them. Like petroleum jelly for me, the nose butter seemed to be “riding on top” and not soaking in. Even at that, it did halt that horrifying split i was seeing between her nostrils-down to raw tissue! So we were still at my concoction in between nose butter three times a day. I finally tried my stuff first with nose butter over it. Voìla! A day later I was checking that sweet little soft black nose a lot more often than I needed to treat it. I am so grateful. That suddenly dry, hot, hard, rough nosie was heartbreaking. My fur baby is a lot happier too. Thank you!